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Is cross-validation valid for small-sample microarray classification?
Author(s) -
Ulisses Braga-Neto,
Edward R. Dougherty
Publication year - 2004
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btg419
Subject(s) - estimator , statistics , cross validation , replicate , computer science , outlier , variance (accounting) , mean squared error , sample size determination , variance inflation factor , pattern recognition (psychology) , artificial intelligence , mathematics , linear regression , accounting , business , multicollinearity
Microarray classification typically possesses two striking attributes: (1) classifier design and error estimation are based on remarkably small samples and (2) cross-validation error estimation is employed in the majority of the papers. Thus, it is necessary to have a quantifiable understanding of the behavior of cross-validation in the context of very small samples.

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