Adjustment of systematic microarray data biases
Author(s) -
Mónica Benito,
Joel S. Parker,
Quan Du,
Junyuan Wu,
Xiang Dong,
Charles M. Perou,
J. S. Marron
Publication year - 2003
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btg385
Subject(s) - computer science , microarray analysis techniques , microarray , microarray databases , data mining , computational biology , statistics , biology , mathematics , genetics , gene , gene expression
Systematic differences due to experimental features of microarray experiments are present in most large microarray data sets. Many different experimental features can cause biases including different sources of RNA, different production lots of microarrays or different microarray platforms. These systematic effects present a substantial hurdle to the analysis of microarray data.
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