Open AccessWILMA—automated annotation of protein sequences
Author(s) -
Andreas Prlić,
Francisco S. Domingues,
Peter Lackner,
Manfred J. Sippl
Publication year - 2003
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btg380
Subject(s) - annotation , proteome , caenorhabditis elegans , computer science , homo sapiens , gene annotation , computational biology , gene ontology , interface (matter) , genome , biology , bioinformatics , gene , genetics , artificial intelligence , sociology , anthropology , gene expression , parallel computing , maximum bubble pressure method , bubble
Large-scale annotation of sets of proteins is a frequently occurring task in association with genome sequencing projects. Here, we present an automated platform for the functional annotation of large sets of protein sequences. Various bioinformatics tools are used to achieve a comprehensive description of protein sequences and to link these results to standard Gene Ontology descriptors for molecular function, biological processes and cellular components. Access to the annotation is provided via a web-interface and database queries. These interfaces allow to formulate proteome wide queries as well as the investigation of details of individual results. WILMA annotations of the proteomes of Homo sapiens, Mus musculus, Arabidopsis thaliana and Caenorhabditis elegans are accessible at http://www.came.sbg.ac.at/wilma/
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