GRIL: genome rearrangement and inversion locator | Zendy

Aaron E. Darling | Zendy; Bob Mau | Zendy; Frederick R. Blattner | Zendy; Nicole T. Perna | Zendy

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GRIL: genome rearrangement and inversion locator

Author(s) -

Aaron E. Darling,

Bob Mau,

Frederick R. Blattner,

Nicole T. Perna

Publication year - 2003

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btg378

Subject(s) - correctness , computer science , genome , sequence (biology) , basis (linear algebra) , set (abstract data type) , data mining , computational biology , algorithm , theoretical computer science , biology , genetics , mathematics , programming language , gene , geometry

GRIL is a tool to automatically identify collinear regions in a set of bacterial-size genome sequences. GRIL uses three basic steps. First, regions of high sequence identity are located. Second, some of these regions are filtered based on user-specified criteria. Finally, the remaining regions of sequence identity are used to define significant collinear regions among the sequences. By locating collinear regions of sequence, GRIL provides a basis for multiple genome alignment using current alignment systems. GRIL also provides a basis for using current inversion distance tools to infer phylogeny.

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