Combining DNA expression with positional information to detect functional silencing of chromosomal regions | Zendy

Johannes Hüsing | Zendy; Michael Zeschnigk | Zendy; Tanja Boes | Zendy; KarlHeinz Jöckel | Zendy

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Combining DNA expression with positional information to detect functional silencing of chromosomal regions

Author(s) -

Johannes Hüsing,

Michael Zeschnigk,

Tanja Boes,

KarlHeinz Jöckel

Publication year - 2003

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btg314

Subject(s) - dna microarray , biology , genetics , gene silencing , gene , computational biology , locus (genetics) , genome , epigenetics , false positive paradox , position effect , gene expression , computer science , artificial intelligence

Loss of chromosomal material is often observed in cancer cells. In this situation the expression of genes is related to their position on the genome. Epigenetic phenomena may also silence several genes in the same region of a chromosome. While cytogenetic or other molecular genetic methods spot changes of DNA copy number, they cannot detect other causes of silencing.

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