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The immunogenicity of peptides depends on their ability to bind to MHC molecules. MHC binding affinity prediction methods can save significant amounts of experimental work. The class II MHC binding site is open at both ends, making epitope prediction difficult because of the multiple binding ability of long peptides.

bioinformatics

Towards the <i>in silico</i> identification of class II restricted T-cell epitopes: a partial least squares iterative self-consistent algorithm for affinity prediction

Towards the in silico identification of class II restricted T-cell epitopes: a partial least squares iterative self-consistent algorithm for affinity prediction