Automatic design of gene-specific sequence tags for genome-wide functional studies | Zendy

Vincent Thareau | Zendy; Patrice Déhais | Zendy; Carine Serizet | Zendy; Pierre Hilson | Zendy; Pierre Rouzé | Zendy; Santiago P. Aubourg | Zendy

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Automatic design of gene-specific sequence tags for genome-wide functional studies

Author(s) -

Vincent Thareau,

Patrice Déhais,

Carine Serizet,

Pierre Hilson,

Pierre Rouzé,

Santiago P. Aubourg

Publication year - 2003

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btg286

Subject(s) - sequence (biology) , computational biology , gene , genome , genetics , biology , computer science

The availability of complete genome sequences allows the identification of short DNA segments that are specific to each annotated gene. Such unique gene sequence tags (GSTs) replace advantageously cDNAs in microarray transcript profiling experiments. In particular, probes corresponding to individual members of multigene families can be chosen carefully to avoid cross-hybridization events.

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