Identifying property based sequence motifs in protein families and superfamilies: application to DNase-1 related endonucleases | Zendy

Venkatarajan S. Mathura | Zendy; Catherine H. Schein | Zendy; Werner Braun | Zendy

Open Access

Identifying property based sequence motifs in protein families and superfamilies: application to DNase-1 related endonucleases

Author(s) -

Venkatarajan S. Mathura,

Catherine H. Schein,

Werner Braun

Publication year - 2003

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btg164

Subject(s) - computational biology , sequence alignment , genetics , sequence motif , biology , sequence database , uniprot , conserved sequence , sequence analysis , multiple sequence alignment , contig , structural alignment , peptide sequence , dna , gene , genome

Identification of short conserved sequence motifs common to a protein family or superfamily can be more useful than overall sequence similarity in suggesting the function of novel gene products. Locating motifs still requires expert knowledge, as automated methods using stringent criteria may not differentiate subtle similarities from statistical noise.

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