New normalization methods for cDNA microarray data | Zendy

David L. Wilson | Zendy; Michael Buckley | Zendy; Chris A. Helliwell | Zendy; Iain W. Wilson | Zendy

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New normalization methods for cDNA microarray data

Author(s) -

David L. Wilson,

Michael Buckley,

Chris A. Helliwell,

Iain W. Wilson

Publication year - 2003

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btg146

Subject(s) - normalization (sociology) , dna microarray , microarray databases , computational biology , complementary dna , microarray , software , microarray analysis techniques , database normalization , computer science , gene expression profiling , data mining , biology , bioinformatics , gene expression , genetics , gene , artificial intelligence , pattern recognition (psychology) , sociology , anthropology , programming language

The focus of this paper is on two new normalization methods for cDNA microarrays. After the image analysis has been performed on a microarray and before differentially expressed genes can be detected, some form of normalization must be applied to the microarrays. Normalization removes biases towards one or other of the fluorescent dyes used to label each mRNA sample allowing for proper evaluation of differential gene expression.

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