Open AccessNon-linear normalization and background correction in one-channel cDNA microarray studies
Author(s) -
David Edwards
Publication year - 2003
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btg083
Subject(s) - smoothing , normalization (sociology) , dna microarray , computer science , computational biology , channel (broadcasting) , biology , algorithm , mathematics , genetics , statistics , gene expression , gene , sociology , anthropology , computer network
Data from one-channel cDNA microarray studies may exhibit poor reproducibility due to spatial heterogeneity, non-linear array-to-array variation and problems in correcting for background. Uncorrected, these phenomena can give rise to misleading conclusions.
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