Codon pairs in the genome of Escherichia coli | Zendy

Svetlana Boycheva | Zendy; Georgi Chkodrov | Zendy; Ivan Ivanov | Zendy

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Codon pairs in the genome of Escherichia coli

Author(s) -

Svetlana Boycheva,

Georgi Chkodrov,

Ivan Ivanov

Publication year - 2003

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btg082

Subject(s) - codon usage bias , genetics , orfs , translation (biology) , biology , start codon , escherichia coli , ribosome , gene , genome , open reading frame , stop codon , transfer rna , computational biology , messenger rna , rna , peptide sequence

The effect of two neighboring codons (codon pairs) on gene expression is mediated via the interaction of their cognate tRNAs occupying the two functional ribosomal sites during the translation elongation step. For steric reasons it is reasonable to assume that not all combinations of codons and therefore of tRNAs are equally favorable when situated on the ribosome surface. Aiming of identifying preferential and rare codon pairs, we have determined the frequency of occurrence of all possible combinations of codon pairs in the entire genome of Escherichia coli (E.coli).

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