A segment alignment approach to protein comparison | Zendy

Yuzhen Ye | Zendy; Lukasz Jaroszewski | Zendy; Weizhong Li | Zendy; Adam Godzik | Zendy

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A segment alignment approach to protein comparison

Author(s) -

Yuzhen Ye,

Lukasz Jaroszewski,

Weizhong Li,

Adam Godzik

Publication year - 2003

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btg073

Subject(s) - multiple sequence alignment , computer science , benchmark (surveying) , position (finance) , local structure , sequence alignment , similarity (geometry) , structural alignment , protein structure , sequence (biology) , alignment free sequence analysis , matching (statistics) , protein structure prediction , graph , algorithm , path (computing) , computational biology , artificial intelligence , theoretical computer science , mathematics , biology , peptide sequence , crystallography , gene , statistics , genetics , image (mathematics) , chemistry , biochemistry , geodesy , programming language , finance , geography , economics

Local structure segments (LSSs) are small structural units shared by unrelated proteins. They are extensively used in protein structure comparison, and predicted LSSs (PLSSs) are used very successfully in ab initio folding simulations. However, predicted or real LSSs are rarely exploited by protein sequence comparison programs that are based on position-by-position alignments.

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