Effective dimension reduction methods for tumor classification using gene expression data
Author(s) -
Anestis Antoniadis,
Sophie LambertLacroix,
Frédérique Leblanc
Publication year - 2003
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btg062
Subject(s) - dimensionality reduction , sliced inverse regression , context (archaeology) , linear discriminant analysis , data set , computer science , nonparametric statistics , data mining , artificial intelligence , reduction (mathematics) , feature selection , mathematics , pattern recognition (psychology) , statistics , biology , paleontology , geometry
One particular application of microarray data, is to uncover the molecular variation among cancers. One feature of microarray studies is the fact that the number n of samples collected is relatively small compared to the number p of genes per sample which are usually in the thousands. In statistical terms this very large number of predictors compared to a small number of samples or observations makes the classification problem difficult. An efficient way to solve this problem is by using dimension reduction statistical techniques in conjunction with nonparametric discriminant procedures.
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