DeepTrio: a ternary prediction system for protein–protein interaction using mask multiple parallel convolutional neural networks
Author(s) -
Xiaotian Hu,
Cong Feng,
Yincong Zhou,
Andrew Harrison,
Ming Chen
Publication year - 2021
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btab737
Subject(s) - computer science , convolutional neural network , generalization , machine learning , artificial intelligence , artificial neural network , ternary operation , data mining , pattern recognition (psychology) , mathematics , mathematical analysis , programming language
Protein-protein interaction (PPI), as a relative property, is determined by two binding proteins, which brings a great challenge to design an expert model with an unbiased learning architecture and a superior generalization performance. Additionally, few efforts have been made to allow PPI predictors to discriminate between relative properties and intrinsic properties.
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