LocalNgsRelate: a software tool for inferring IBD sharing along the genome between pairs of individuals from low-depth NGS data | Zendy

Alissa L. Severson | Zendy; Thorfinn Sand Korneliussen | Zendy; Ida Moltke | Zendy

Open Access

LocalNgsRelate: a software tool for inferring IBD sharing along the genome between pairs of individuals from low-depth NGS data

Author(s) -

Alissa L. Severson,

Thorfinn Sand Korneliussen,

Ida Moltke

Publication year - 2021

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btab732

Subject(s) - inference , computer science , genome , identity by descent , genotype , software , data mining , 1000 genomes project , computational biology , dna sequencing , genome wide association study , probabilistic logic , biology , artificial intelligence , genetics , haplotype , single nucleotide polymorphism , gene , programming language

Inference of identity-by-descent (IBD) sharing along the genome between pairs of individuals has important uses. But all existing inference methods are based on genotypes, which is not ideal for low-depth Next Generation Sequencing (NGS) data from which genotypes can only be called with high uncertainty.

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