Optimal linkage disequilibrium splitting | Zendy

Florian Privé | Zendy

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Optimal linkage disequilibrium splitting

Author(s) -

Florian Privé

Publication year - 2021

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btab519

Subject(s) - linkage disequilibrium , linkage (software) , disequilibrium , computer science , genetics , computational biology , biology , haplotype , allele , medicine , gene , ophthalmology

Motivation A few algorithms have been developed for splitting the genome in nearly independent blocks of linkage disequilibrium. Due to the complexity of this problem, these algorithms rely on heuristics, which makes them suboptimal. Results Here, we develop an optimal solution for this problem using dynamic programming. Availability This is now implemented as function snp_ldsplit as part of R package bigsnpr. Supplementary information Supplementary data are available at Bioinformatics online.

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