NeuralPolish: a novel Nanopore polishing method based on alignment matrix construction and orthogonal Bi-GRU Networks | Zendy

Neng Huang | Zendy; Fan Nie | Zendy; Peng Ni | Zendy; Feng Luo | Zendy; Xin Gao | Zendy; Jianxin Wang | Zendy

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NeuralPolish: a novel Nanopore polishing method based on alignment matrix construction and orthogonal Bi-GRU Networks

Author(s) -

Neng Huang,

Fan Nie,

Peng Ni,

Feng Luo,

Xin Gao,

Jianxin Wang

Publication year - 2021

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btab354

Subject(s) - polishing , contig , computer science , column (typography) , sequence assembly , matrix (chemical analysis) , algorithm , nanopore , nanopore sequencing , feature (linguistics) , data mining , engineering drawing , pattern recognition (psychology) , genome , artificial intelligence , engineering , materials science , nanotechnology , mechanical engineering , biology , telecommunications , biochemistry , gene expression , linguistics , philosophy , transcriptome , frame (networking) , composite material , gene

Oxford Nanopore sequencing producing long reads at low cost has made many breakthroughs in genomics studies. However, the large number of errors in Nanopore genome assembly affect the accuracy of genome analysis. Polishing is a procedure to correct the errors in genome assembly and can improve the reliability of the downstream analysis. However, the performances of the existing polishing methods are still not satisfactory.

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