VIRUSBreakend: Viral Integration Recognition Using Single Breakends | Zendy

Daniel Cameron | Zendy; Nina Jacobs | Zendy; Paul Roepman | Zendy; Peter Priestley | Zendy; Edwin Cuppen | Zendy; Anthony T. Papenfuss | Zendy

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VIRUSBreakend: Viral Integration Recognition Using Single Breakends

Author(s) -

Daniel Cameron,

Nina Jacobs,

Paul Roepman,

Peter Priestley,

Edwin Cuppen,

Anthony T. Papenfuss

Publication year - 2021

Publication title -

bioinformatics

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btab343

Subject(s) - genome , computational biology , biology , genomics , breakpoint , host (biology) , software , computer science , genetics , gene , chromosomal translocation , programming language

Integration of viruses into infected host cell DNA can cause DNA damage and disrupt genes. Recent cost reductions and growth of whole genome sequencing has produced a wealth of data in which viral presence and integration detection is possible. While key research and clinically relevant insights can be uncovered, existing software has not achieved widespread adoption, limited in part due to high computational costs, the inability to detect a wide range of viruses, as well as precision and sensitivity.

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