Open AccessQuantification of cell behaviors and computational modeling show that cell directional behaviors drive zebrafish pectoral fin morphogenesis
Author(s) -
Joel Dokmegang,
Hanh T. Nguyen,
Eléna Kardash,
Thierry Savy,
Matteo Cavaliere,
Nadine Peyriéras,
René Doursat
Publication year - 2021
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btab201
Subject(s) - morphogenesis , zebrafish , fish fin , biology , fin , microbiology and biotechnology , anatomy , genetics , fish <actinopterygii> , materials science , fishery , gene , composite material
Understanding the mechanisms by which the zebrafish pectoral fin develops is expected to produce insights on how vertebrate limbs grow from a 2D cell layer to a 3D structure. Two mechanisms have been proposed to drive limb morphogenesis in tetrapods: a growth-based morphogenesis with a higher proliferation rate at the distal tip of the limb bud than at the proximal side, and directed cell behaviors that include elongation, division and migration in a non-random manner. Based on quantitative experimental biological data at the level of individual cells in the whole developing organ, we test the conditions for the dynamics of pectoral fin early morphogenesis.