Fast detection of differential chromatin domains with SCIDDO | Zendy

Peter Ebert | Zendy; Marcel H. Schulz | Zendy

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Fast detection of differential chromatin domains with SCIDDO

Author(s) -

Peter Ebert,

Marcel H. Schulz

Publication year - 2020

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btaa960

Subject(s) - chromatin , epigenome , computational biology , chromatin immunoprecipitation , epigenomics , histone , biology , histone code , epigenetics , computer science , genetics , gene , nucleosome , gene expression , dna methylation , promoter

The generation of genome-wide maps of histone modifications using chromatin immunoprecipitation sequencing is a standard approach to dissect the complexity of the epigenome. Interpretation and differential analysis of histone datasets remains challenging due to regulatory meaningful co-occurrences of histone marks and their difference in genomic spread. To ease interpretation, chromatin state segmentation maps are a commonly employed abstraction combining individual histone marks. We developed the tool SCIDDO as a fast, flexible and statistically sound method for the differential analysis of chromatin state segmentation maps.

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