Open AccessInferring TF activities and activity regulators from gene expression data with constraints from TF perturbation data
Author(s) -
Z. Cynthia,
Michael R. Brent
Publication year - 2020
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btaa947
Subject(s) - computational biology , gene expression , gene expression profiling , gene , computer science , biology , data mining , genetics
The activity of a transcription factor (TF) in a sample of cells is the extent to which it is exerting its regulatory potential. Many methods of inferring TF activity from gene expression data have been described, but due to the lack of appropriate large-scale datasets, systematic and objective validation has not been possible until now.
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