Open AccessProtein residues determining interaction specificity in paralogous families
Author(s) -
Borja Pitarch,
Juan A. G. Ranea,
Florencio Pazos
Publication year - 2020
Publication title -
bioinformatics
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btaa934
Subject(s) - interactome , pairwise comparison , sequence (biology) , computational biology , computer science , set (abstract data type) , multiple sequence alignment , biology , sequence alignment , data mining , theoretical computer science , peptide sequence , genetics , artificial intelligence , gene , programming language
Predicting the residues controlling a protein's interaction specificity is important not only to better understand its interactions but also to design mutations aimed at fine-tuning or swapping them as well.
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