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panRGP: a pangenome-based method to predict genomic islands and explore their diversity
Author(s) -
Adelme Bazin,
Guillaume Gautreau,
Claudine Médigue,
David Vallenet,
Alexandra Calteau
Publication year - 2020
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btaa792
Subject(s) - diversity (politics) , computational biology , biology , evolutionary biology , computer science , sociology , anthropology
Horizontal gene transfer (HGT) is a major source of variability in prokaryotic genomes. Regions of genome plasticity (RGPs) are clusters of genes located in highly variable genomic regions. Most of them arise from HGT and correspond to genomic islands (GIs). The study of those regions at the species level has become increasingly difficult with the data deluge of genomes. To date, no methods are available to identify GIs using hundreds of genomes to explore their diversity.

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