A database of flavivirus RNA structures with a search algorithm for pseudoknots and triple base interactions | Zendy

Alan Zammit | Zendy; Leon Helwerda | Zendy; René C. L. Olsthoorn | Zendy; Fons J. Verbeek | Zendy; Alexander P. Gultyaev | Zendy

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A database of flavivirus RNA structures with a search algorithm for pseudoknots and triple base interactions

Author(s) -

Alan Zammit,

Leon Helwerda,

René C. L. Olsthoorn,

Fons J. Verbeek,

Alexander P. Gultyaev

Publication year - 2020

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btaa759

Subject(s) - flavivirus , computational biology , biology , rna , untranslated region , nucleic acid secondary structure , genome , genetics , virology , virus , gene

The Flavivirus genus includes several important pathogens, such as Zika, dengue and yellow fever virus. Flavivirus RNA genomes contain a number of functionally important structures in their 3' untranslated regions (3'UTRs). Due to the diversity of sequences and topologies of these structures, their identification is often difficult. In contrast, predictions of such structures are important for understanding of flavivirus replication cycles and development of antiviral strategies.

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