Decombinator V4: an improved AIRR-C compliant-software package for T-cell receptor sequence annotation?
Author(s) -
Thomas Peacock,
James Heather,
Tahel Ronel,
Benny Chain
Publication year - 2020
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btaa758
Subject(s) - annotation , software , computer science , software package , sequence (biology) , computational biology , chemistry , artificial intelligence , biology , programming language , biochemistry
Analysis of the T-cell receptor repertoire is rapidly entering the general toolbox used by researchers interested in cellular immunity. The annotation of T-cell receptors (TCRs) from raw sequence data poses specific challenges, which arise from the fact that TCRs are not germline encoded, and because of the stochastic nature of the generating process.
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