Uncovering antibody cross-reaction dynamics in influenza A infections | Zendy

Gustavo Hernández-Mejía | Zendy; Esteban A. Hernandez–Vargas | Zendy

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Uncovering antibody cross-reaction dynamics in influenza A infections

Author(s) -

Gustavo Hernández-Mejía,

Esteban A. Hernandez–Vargas

Publication year - 2020

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btaa691

Subject(s) - antibody , computer science , pandemic , population , virology , covid-19 , immunology , biology , medicine , disease , environmental health , pathology , infectious disease (medical specialty)

Influenza viruses are a cause of large outbreaks and pandemics with high death tolls. A key obstacle is that flu vaccines have inconsistent performance, in the best cases up to 60% effectiveness, but it can be as low as 10%. Uncovering the hidden pathways of how antibodies (Abs) induced by one influenza strain are effective against another, cross-reaction, is a central vexation for the design of universal flu vaccines.

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