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Triplet-based similarity score for fully multilabeled trees with poly-occurring labels
Author(s) -
Simone Ciccolella,
Giulia Bernardini,
Luca Denti,
Paola Bonizzoni,
Marco Previtali,
Gianluca Della Vedova
Publication year - 2020
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btaa676
Subject(s) - similarity (geometry) , computer science , range (aeronautics) , tree (set theory) , measure (data warehouse) , mutation , data mining , cluster (spacecraft) , information retrieval , artificial intelligence , machine learning , biology , gene , mathematics , genetics , mathematical analysis , materials science , image (mathematics) , composite material , programming language
The latest advances in cancer sequencing, and the availability of a wide range of methods to infer the evolutionary history of tumors, have made it important to evaluate, reconcile and cluster different tumor phylogenies. Recently, several notions of distance or similarities have been proposed in the literature, but none of them has emerged as the golden standard. Moreover, none of the known similarity measures is able to manage mutations occurring multiple times in the tree, a circumstance often occurring in real cases.

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