Allele-specific multi-sample copy number segmentation in ASCAT | Zendy

Edith Ross | Zendy; Kerstin Haase | Zendy; Peter Van Loo | Zendy; Florian Markowetz | Zendy

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Allele-specific multi-sample copy number segmentation in ASCAT

Author(s) -

Edith Ross,

Kerstin Haase,

Peter Van Loo,

Florian Markowetz

Publication year - 2020

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btaa538

Subject(s) - segmentation , phylogenetic tree , copy number analysis , allele , inference , copy number variation , biology , computer science , sample (material) , trace (psycholinguistics) , genetics , computational biology , artificial intelligence , genome , gene , chemistry , chromatography , linguistics , philosophy

Allele-specific copy number alterations are commonly used to trace the evolution of tumours. A key step of the analysis is to segment genomic data into regions of constant copy number. For precise phylogenetic inference, breakpoints shared between samples need to be aligned to each other.

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