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Motivation    genozip  is a new lossless compression tool for Variant Call Format (VCF) files. By applying field-specific algorithms and fully utilizing the available computational hardware,  genozip  achieves the highest compression ratios amongst existing lossless compression tools known to the authors, at speeds comparable with the fastest multi-threaded compressors.    Availability and implementation    genozip  is freely available to non-commercial users. It can be installed via conda-forge, Docker Hub, or downloaded from github.com/divonlan/genozip.    Supplementary information    Supplementary data  are available at  Bioinformatics  online.

genozip: a fast and efficient compression tool for VCF files