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PPTPP: a novel therapeutic peptide prediction method using physicochemical property encoding and adaptive feature representation learning
Author(s) -
Yu P. Zhang,
Quan Zou
Publication year - 2020
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btaa275
Subject(s) - computer science , identification (biology) , soundness , feature (linguistics) , machine learning , artificial intelligence , comparability , property (philosophy) , representation (politics) , encoding (memory) , data mining , mathematics , biology , linguistics , philosophy , botany , epistemology , combinatorics , politics , political science , law , programming language
Peptide is a promising candidate for therapeutic and diagnostic development due to its great physiological versatility and structural simplicity. Thus, identifying therapeutic peptides and investigating their properties are fundamentally important. As an inexpensive and fast approach, machine learning-based predictors have shown their strength in therapeutic peptide identification due to excellences in massive data processing. To date, no reported therapeutic peptide predictor can perform high-quality generic prediction and informative physicochemical properties (IPPs) identification simultaneously.

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