APAlyzer: a bioinformatics package for analysis of alternative polyadenylation isoforms | Zendy

Ruijia Wang | Zendy; Bin Tian | Zendy

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APAlyzer: a bioinformatics package for analysis of alternative polyadenylation isoforms

Author(s) -

Ruijia Wang,

Bin Tian

Publication year - 2020

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btaa266

Subject(s) - r package , polyadenylation , computational biology , gene isoform , bioinformatics , computer science , focus (optics) , biology , genetics , programming language , messenger rna , gene , physics , optics

Most eukaryotic genes produce alternative polyadenylation (APA) isoforms. APA is dynamically regulated under different growth and differentiation conditions. Here, we present a bioinformatics package, named APAlyzer, for examining 3'UTR APA, intronic APA and gene expression changes using RNA-seq data and annotated polyadenylation sites in the PolyA_DB database. Using APAlyzer and data from the GTEx database, we present APA profiles across human tissues.

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