Open AccessCNV-BAC: Copy number Variation Detection in Bacterial Circular Genome
Author(s) -
Linjie Wu,
Han Wang,
Yuchao Xia,
Ruibin Xi
Publication year - 2020
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btaa208
Subject(s) - copy number variation , replication (statistics) , genome , bacterial genome size , biology , computational biology , genetics , computer science , gene , virology
Whole-genome sequencing (WGS) is widely used for copy number variation (CNV) detection. However, for most bacteria, their circular genome structure and high replication rate make reads more enriched near the replication origin. CNV detection based on read depth could be seriously influenced by such replication bias.
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