The Glycine Receptor Allosteric Ligands Library (GRALL) | Zendy

Adrien Henri Cerdan | Zendy; Marion Sisquellas | Zendy; Gilberto P. Pereira | Zendy; Diego E. B. Gomes | Zendy; JeanPierre Changeux | Zendy; Marco Cecchini | Zendy

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The Glycine Receptor Allosteric Ligands Library (GRALL)

Author(s) -

Adrien Henri Cerdan,

Marion Sisquellas,

Gilberto P. Pereira,

Diego E. B. Gomes,

JeanPierre Changeux,

Marco Cecchini

Publication year - 2020

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btaa170

Subject(s) - allosteric regulation , glycine receptor , homomeric , drug discovery , cooperativity , computational biology , radioligand , ion channel , chemistry , binding site , receptor , biology , glycine , biochemistry , protein subunit , amino acid , gene

Glycine receptors (GlyRs) mediate fast inhibitory neurotransmission in the brain and have been recognized as key pharmacological targets for pain. A large number of chemically diverse compounds that are able to modulate GlyR function both positively and negatively have been reported, which provides useful information for the development of pharmacological strategies and models for the allosteric modulation of these ion channels.

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