PhyloCorrelate: inferring bacterial gene–gene functional associations through large-scale phylogenetic profiling | Zendy

Benjamin J.-M. Tremblay | Zendy; Briallen Lobb | Zendy; Andrew C. Doxey | Zendy

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PhyloCorrelate: inferring bacterial gene–gene functional associations through large-scale phylogenetic profiling

Author(s) -

Benjamin J.-M. Tremblay,

Briallen Lobb,

Andrew C. Doxey

Publication year - 2020

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btaa1105

Subject(s) - phylogenetic tree , computational biology , profiling (computer programming) , gene , biology , genetics , computer science , operating system

Statistical detection of co-occurring genes across genomes, known as 'phylogenetic profiling', is a powerful bioinformatic technique for inferring gene-gene functional associations. However, this can be a challenging task given the size and complexity of phylogenomic databases, difficulty in accounting for phylogenetic structure, inconsistencies in genome annotation and substantial computational requirements.

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