SurfaceGenie: a web-based application for prioritizing cell-type-specific marker candidates | Zendy

Matthew Waas | Zendy; Shana Terai Snarrenberg | Zendy; Jack Littrell | Zendy; Rachel A. Jones | Zendy; Polly A. Hansen | Zendy; John A. Corbett | Zendy; Rebekah L. Gundry | Zendy

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SurfaceGenie: a web-based application for prioritizing cell-type-specific marker candidates

Author(s) -

Matthew Waas,

Shana Terai Snarrenberg,

Jack Littrell,

Rachel A. Jones,

Polly A. Hansen,

John A. Corbett,

Rebekah L. Gundry

Publication year - 2020

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btaa092

Subject(s) - computer science , type (biology) , web application , world wide web , computational biology , biology , ecology

Cell-type-specific surface proteins can be exploited as valuable markers for a range of applications including immunophenotyping live cells, targeted drug delivery and in vivo imaging. Despite their utility and relevance, the unique combination of molecules present at the cell surface are not yet described for most cell types. A significant challenge in analyzing 'omic' discovery datasets is the selection of candidate markers that are most applicable for downstream applications.

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