iPAC: a genome-guided assembler of isoforms via phasing and combing paths
Author(s) -
Ting Yu,
Juntao Liu,
Xin Gao,
Guojun Li
Publication year - 2020
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btaa052
Subject(s) - combing , phaser , computer science , focus (optics) , software , genome , computational biology , sequence assembly , algorithm , programming language , biology , genetics , physics , gene , materials science , transcriptome , gene expression , optics , composite material
Full-length transcript reconstruction is very important and quite challenging for the widely used RNA-seq data analysis. Currently, available RNA-seq assemblers generally suffered from serious limitations in practical applications, such as low assembly accuracy and incompatibility with latest alignment tools.
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