Visualization of circular RNAs and their internal splicing events from transcriptomic data | Zendy

Yi Zheng | Zendy; Fangqing Zhao | Zendy

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Visualization of circular RNAs and their internal splicing events from transcriptomic data

Author(s) -

Yi Zheng,

Fangqing Zhao

Publication year - 2020

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btaa033

Subject(s) - visualization , rna splicing , circular rna , transcriptome , computational biology , alternative splicing , biology , software , computer science , data mining , bioinformatics , gene isoform , rna , genetics , gene , gene expression , programming language

Circular RNAs (circRNAs) are proved to have unique compositions and splicing events distinct from canonical mRNAs. However, there is no visualization tool designed for the exploration of complex splicing patterns in circRNA transcriptomes. Here, we present CIRI-vis, a Java command-line tool for quantifying and visualizing circRNAs by integrating the alignments and junctions of circular transcripts. CIRI-vis can be applied to visualize the internal structure and isoform abundance of circRNAs and perform circRNA transcriptome comparison across multiple samples.

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