The generation of long telomere overhangs in human cells: a model and its implication | Zendy

Yuhua Hao | Zendy; Zheng Tan | Zendy

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The generation of long telomere overhangs in human cells: a model and its implication

Author(s) -

Yuhua Hao,

Zheng Tan

Publication year - 2002

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/18.5.666

Subject(s) - telomere , computational biology , biology , computer science , genetics , dna

Linear chromosomes carry on both ends repetitive DNA sequences called telomere. In the conventional model of semi-conservative DNA replication, the 3'-end of a linear DNA strand cannot be fully replicated, resulting in a single-stranded 3' overhang at one end of the double-stranded DNA product. In this model, the length of the overhang is expected to be about the size of an RNA primer (about nine nucleotides for human cells). However, it has been found that the telomere overhangs in human cells can be as long as several hundred nucleotides. At present, the opinion regarding how such long overhangs are produced is controversial.

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