INCLUSive: INtegrated Clustering, Upstream sequence retrieval and motif Sampling
Author(s) -
Gert Thijs,
Yves Moreau,
Frank De Smet,
Janick Mathys,
Magali Lescot,
Stéphane Rombauts,
Pierre Rouzé,
Bart De Moor,
Kathleen Marchal
Publication year - 2002
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/18.2.331
Subject(s) - cluster analysis , sequence motif , motif (music) , computer science , sampling (signal processing) , sequence (biology) , computational biology , artificial intelligence , data mining , biology , genetics , computer vision , physics , acoustics , dna , filter (signal processing)
INCLUSive allows automatic multistep analysis of microarray data (clustering and motif finding). The clustering algorithm (adaptive quality-based clustering) groups together genes with highly similar expression profiles. The upstream sequences of the genes belonging to a cluster are automatically retrieved from GenBank and can be fed directly into Motif Sampler, a Gibbs sampling algorithm that retrieves statistically over-represented motifs in sets of sequences, in this case upstream regions of co-expressed genes.
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