Improved database searches for orthologous sequences by conditioning on outgroup sequences | Zendy

Philip J. Cotter | Zendy; Daniel R. Caffrey | Zendy; Denis C. Shields | Zendy

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Improved database searches for orthologous sequences by conditioning on outgroup sequences

Author(s) -

Philip J. Cotter,

Daniel R. Caffrey,

Denis C. Shields

Publication year - 2002

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/18.1.83

Subject(s) - outgroup , conditioning , biology , sequence (biology) , computational biology , genetics , computer science , mathematics , statistics , paleontology

Searches of biological sequence databases are usually focussed on distinguishing significant from random matches. However, the increasing abundance of related sequences on databases present a second challenge: to distinguish the evolutionarily most closely related sequences (often orthologues) from more distantly related homologues. This is particularly important when searching a database of partial sequences, where short orthologous sequences from a non-conserved region will score much more poorly than non-orthologous (outgroup) sequences from a conserved region.

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