A fast top–down method for constructing reliable radiation hybrid frameworks | Zendy

Trond Hellem Bø | Zendy; Inge Jonassen | Zendy; Ingvar Eidhammer | Zendy; Carsten Helgesen | Zendy

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A fast top–down method for constructing reliable radiation hybrid frameworks

Author(s) -

Trond Hellem Bø,

Inge Jonassen,

Ingvar Eidhammer,

Carsten Helgesen

Publication year - 2002

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/18.1.11

Subject(s) - computer science , contig , set (abstract data type) , chromosome , radiation hybrid mapping , data mining , genome , theoretical computer science , gene mapping , genetics , biology , gene , programming language

Radiation Hybrid Mapping (RHM) is a technique used to order a set of markers on a genome and estimating physical distances between them. RHM provides information on marker placement independent from other methods such as sequencing, and can therefore be used for example in genome sequencing to help ordering contigs. A radiation hybrid framework can be constructed by choosing a set of markers so that the chromosome coverage is good and so that the markers can be ordered with high confidence. Automatically constructing RHM frameworks is a computationally challenging problem.

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