Open AccessLimits of homology detection by pairwise sequence comparison
Author(s) -
Rainer Spang,
Martin Vingron
Publication year - 2001
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/17.4.338
Subject(s) - pairwise comparison , homology (biology) , computational biology , sequence homology , sequence (biology) , computer science , biology , genetics , artificial intelligence , base sequence , gene
Noise in database searches resulting from random sequence similarities increases as the databases expand rapidly. The noise problems are not a technical shortcoming of the database search programs, but a logical consequence of the idea of homology searches. The effect can be observed in simulation experiments.
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