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Use of keyword hierarchies to interpret gene expression patterns
Author(s) -
Daniel R. Masys,
John Welsh,
J. Lynn Fink,
Michael Gribskov,
Igor Klacansky,
Jacques Corbeil
Publication year - 2001
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/17.4.319
Subject(s) - cluster analysis , information retrieval , variety (cybernetics) , computer science , interpretation (philosophy) , hierarchical clustering , search engine indexing , expression (computer science) , subject (documents) , similarity (geometry) , computational biology , data science , data mining , artificial intelligence , biology , library science , image (mathematics) , programming language
High-density microarray technology permits the quantitative and simultaneous monitoring of thousands of genes. The interpretation challenge is to extract relevant information from this large amount of data. A growing variety of statistical analysis approaches are available to identify clusters of genes that share common expression characteristics, but provide no information regarding the biological similarities of genes within clusters. The published literature provides a potential source of information to assist in interpretation of clustering results.

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