Flexibility of the genetic code with respect to DNA structure | Zendy

Pierre-François Baisnée | Zendy; Pierre Baldi | Zendy; Søren Brunak | Zendy; Anders Gorm Pedersen | Zendy

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Flexibility of the genetic code with respect to DNA structure

Author(s) -

Pierre-François Baisnée,

Pierre Baldi,

Søren Brunak,

Anders Gorm Pedersen

Publication year - 2001

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/17.3.237

Subject(s) - flexibility (engineering) , genetic code , code (set theory) , computer science , dna , computational biology , programming language , genetics , biology , mathematics , statistics , set (abstract data type)

The primary function of DNA is to carry genetic information through the genetic code. DNA, however, contains a variety of other signals related, for instance, to reading frame, codon bias, pairwise codon bias, splice sites and transcription regulation, nucleosome positioning and DNA structure. Here we study the relationship between the genetic code and DNA structure and address two questions. First, to which degree does the degeneracy of the genetic code and the acceptable amino acid substitution patterns allow for the superimposition of DNA structural signals to protein coding sequences? Second, is the origin or evolution of the genetic code likely to have been constrained by DNA structure?

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