Sequence-structure specificity of a knowledge based energy function at the secondary structure level | Zendy

Dong Xu | Zendy; M.A. Unseren | Zendy; Yichun Xu | Zendy; Edward C. Uberbacher | Zendy

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Sequence-structure specificity of a knowledge based energy function at the secondary structure level

Author(s) -

Dong Xu,

M.A. Unseren,

Yichun Xu,

Edward C. Uberbacher

Publication year - 2000

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/16.3.257

Subject(s) - sequence (biology) , function (biology) , computer science , energy (signal processing) , computational biology , mathematics , biology , genetics , statistics

This paper investigates the sequence-structure specificity of a representative knowledge based energy function by applying it to threading at the level of secondary structures of proteins. Assessing the strengths and weaknesses of an energy function at this fundamental level provides more detailed and insightful information than at the tertiary structure level and the results obtained can be useful in tertiary level threading.

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