Open AccessProtein domain decomposition using a graph-theoretic approach
Author(s) -
Ying Xu,
Dong Xu,
Harold N. Gabow
Publication year - 2000
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/16.12.1091
Subject(s) - domain decomposition methods , computer science , domain (mathematical analysis) , bottleneck , algorithm , graph , decomposition , decomposition method (queueing theory) , mathematical optimization , mathematics , theoretical computer science , discrete mathematics , mathematical analysis , ecology , physics , finite element method , biology , thermodynamics , embedded system
Automatic decomposition of a multi-domain protein into individual domains represents a highly interesting and unsolved problem. As the number of protein structures in PDB is growing at an exponential rate, there is clearly a need for more reliable and efficient methods for protein domain decomposition simply to keep the domain databases up-to-date.
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