Open AccessStatistical mechanical simulation of polymeric DNA melting with MELTSIM.
Author(s) -
R. D. Blake,
Jeffrey W. Bizzaro,
J.D. Blake,
G. Day,
Scott G. Delcourt,
Joshua Knowles,
Kenneth A. Marx,
John SantaLucia
Publication year - 1999
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/15.5.370
Subject(s) - melting temperature , sequence (biology) , computational biology , plasmid , coding region , genbank , dna , crystallography , biology , materials science , chemistry , genetics , gene , composite material
MELTSIM is a windows-based statistical mechanical program for simulating melting curves of DNAs of known sequence and genomic dimensions under different conditions of ionic strength with great accuracy. The program is useful for mapping variations of base compositions of sequences, conducting studies of denaturation, establishing appropriate conditions for hybridization and renaturation, determinations of sequence complexity, and sequence divergence.
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