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Transitive sequence matching expands the scope of sequence comparison by re-running the results of a given query against the databank as a new query. This sometimes results in the initial query sequence (Q) being related to a final match (M) indirectly, through a third, 'intermediate' sequence (Q --&gt; I --&gt; M ). This approach has often been suggested as providing greater sensitivity in sequence comparison; however, it has not yet been possible to gauge its improvement precisely.

Measurement of the effectiveness of transitive sequence comparison, through a third 'intermediate' sequence.