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Measurement of the effectiveness of transitive sequence comparison, through a third 'intermediate' sequence.
Author(s) -
Mark Gerstein
Publication year - 1998
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/14.8.707
Subject(s) - transitive relation , sequence (biology) , pairwise comparison , set (abstract data type) , matching (statistics) , false positive paradox , computer science , test set , mathematics , algorithm , combinatorics , artificial intelligence , biology , genetics , statistics , programming language
Transitive sequence matching expands the scope of sequence comparison by re-running the results of a given query against the databank as a new query. This sometimes results in the initial query sequence (Q) being related to a final match (M) indirectly, through a third, 'intermediate' sequence (Q --> I --> M ). This approach has often been suggested as providing greater sensitivity in sequence comparison; however, it has not yet been possible to gauge its improvement precisely.

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