Open AccessAssessing protein coding region integrity in cDNA sequencing projects.
Author(s) -
Asaf Salamov,
Tetsuo Nishikawa,
Mark B. Swindells
Publication year - 1998
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/14.5.384
Subject(s) - complementary dna , coding region , computational biology , genetics , biology , sequence (biology) , computer science , stop codon , algorithm , gene
In cDNA sequencing projects, it is vital to know whether the protein coding region of a sequence is complete, or whether errors have occurred during library construction. Here we present a linear discriminant approach that predicts this completeness by estimating the probability of each ATG being the initiation codon.
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