Open AccessFrame: detection of genomic sequencing errors.
Author(s) -
Nigel P. Brown,
Chris Sander,
Peer Bork
Publication year - 1998
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/14.4.367
Subject(s) - orfs , open reading frame , frameshift mutation , reading frame , genetics , computational biology , biology , genomic dna , genome , dna sequencing , gene , coding region , stop codon , computer science , peptide sequence , mutation
The underlying error rate for genomic sequencing sometimes results in the introduction of artificial frameshifts and in-frame stop codons into putative protein encoding genes. Severe errors are then introduced into the inferred transcripts through mis-translation or premature termination.
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